Tratat De Farmacologie Aurelia Nicoleta Cristea.pdf
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Tratat de Farmacologie by Aurelia Nicoleta Cristea
Tratat de Farmacologie is a comprehensive textbook of pharmacology written by Aurelia Nicoleta Cristea, a professor of pharmacology at the University of Medicine and Pharmacy "Carol Davila" in Bucharest, Romania. The book covers the basic principles of pharmacology, as well as the pharmacodynamics and pharmacokinetics of various classes of drugs, such as analgesics, anti-inflammatory agents, antibiotics, antivirals, antifungals, antiparasitics, antineoplastics, immunomodulators, cardiovascular drugs, respiratory drugs, gastrointestinal drugs, endocrine drugs, psychotropic drugs, and drugs acting on the nervous system. The book also includes chapters on pharmacogenetics, pharmacovigilance, drug interactions, drug development, and clinical trials.
The book was published in 2012 by Editura Medicala and has 1330 pages. It is written in Romanian and is intended for medical students, residents, and practitioners who want to update their knowledge on pharmacology. The book is based on the latest scientific evidence and international guidelines and provides clear explanations, examples, tables, figures, and algorithms to facilitate learning and understanding. The book also contains self-assessment questions and answers at the end of each chapter to help readers evaluate their progress.
Tratat de Farmacologie is a valuable resource for anyone interested in the science and practice of pharmacology. It is one of the most comprehensive and authoritative books on pharmacology in Romania and has received positive reviews from experts and readers alike. The book can be purchased online from various online bookstores[^2^] [^3^] or downloaded as a PDF file from some websites[^1^]. However, downloading the PDF file may violate the copyright of the author and publisher.In this article, we will review some of the main topics covered in Tratat de Farmacologie by Aurelia Nicoleta Cristea. We will highlight the key concepts, mechanisms, and applications of pharmacology in various clinical scenarios. We will also provide some examples of drugs and their effects on the human body.
Basic Principles of Pharmacology
Pharmacology is the study of the interactions between drugs and living organisms. Drugs are substances that can modify the physiological functions of the body by binding to specific targets, such as receptors, enzymes, transporters, or ion channels. The term drug can refer to both natural and synthetic compounds, as well as endogenous substances that act as hormones or neurotransmitters.
The main objectives of pharmacology are to understand how drugs work, how they are absorbed, distributed, metabolized, and eliminated by the body, how they can be used to prevent or treat diseases, and how they can cause adverse effects or interactions with other drugs or food. To achieve these objectives, pharmacology relies on various disciplines, such as chemistry, biochemistry, physiology, pathology, microbiology, immunology, genetics, and statistics.
Some of the basic principles of pharmacology are:
Dose-response relationship: The relationship between the amount of drug administered and the intensity or duration of its effect. The dose-response curve can be used to determine the potency (the amount of drug needed to produce a certain effect), the efficacy (the maximal effect that can be achieved by a drug), and the therapeutic index (the ratio between the toxic dose and the effective dose) of a drug.
Pharmacodynamics: The study of the biochemical and physiological effects of drugs and their mechanisms of action. Pharmacodynamics involves the analysis of the affinity (the strength of binding) and the intrinsic activity (the ability to activate) of drugs to their targets, as well as the modulation of these targets by various factors, such as agonists (drugs that activate or enhance the target), antagonists (drugs that block or inhibit the target), partial agonists (drugs that have both agonist and antagonist properties), inverse agonists (drugs that produce an opposite effect to agonists), and allosteric modulators (drugs that bind to a different site than the target and alter its function).
Pharmacokinetics: The study of the movement of drugs within the body. Pharmacokinetics involves the analysis of the absorption (the entry of drugs into the bloodstream), distribution (the delivery of drugs to different tissues and organs), metabolism (the chemical transformation of drugs by enzymes), and excretion (the elimination of drugs or their metabolites from the body) of drugs. Pharmacokinetics can be influenced by various factors, such as route of administration (oral, intravenous, intramuscular, subcutaneous, etc.), bioavailability (the fraction of drug that reaches the systemic circulation), volume of distribution (the apparent space in which a drug is distributed), clearance (the rate at which a drug is removed from the body), half-life (the time required for a drug concentration to decrease by half), and steady state (the condition in which the rate of drug input equals the rate of drug output). 061ffe29dd